Sdc4 | syndecan 4

GeneMGI:1349164Synonyms: S4, Synd4, +2 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Cardiovascular system

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased neutrophil cell number	2 supporting datasets	Sdc4^{tm2b(KOMP)Wtsi}	homozygote	Early adult	2.01x10^-11
decreased circulating total protein level	1 supporting dataset	Sdc4^{tm2b(KOMP)Wtsi}	homozygote	Early adult	7.91x10^-5
abnormal retina blood vessel morphology	1 supporting dataset	Sdc4^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	5.09x10^-5
decreased mean platelet volume	1 supporting dataset	Sdc4^{tm2b(KOMP)Wtsi}	homozygote	Early adult	2.63x10^-5
decreased lymphocyte cell number	1 supporting dataset	Sdc4^{tm2b(KOMP)Wtsi}	homozygote	Early adult	6.96x10^-9
increased red blood cell distribution width	1 supporting dataset	Sdc4^{tm2b(KOMP)Wtsi}	homozygote	Early adult	1.31x10^-7
mydriasis	1 supporting dataset	Sdc4^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	7.33x10^-8
decreased circulating serum albumin level	1 supporting dataset	Sdc4^{tm2b(KOMP)Wtsi}	homozygote	Early adult	8.12x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sdc4.

Associated images

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Histopathology

There is no histopathology data found for Sdc4.

IMPC related publications

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External links

No external links available for Sdc4.

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*Sdc4^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Sdc4^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sdc4^{tm2b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sdc4^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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