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Gene: Ceacam1 MGI:1347245

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
CEA cell adhesion molecule 1
Synonyms:
Bgp,  Bgp1,  Hv2,  Cc1,  Hv-2,  Cea-7,  Mhv-1,  Cea-1,  MHVR1,  Cea1,  Cea7,  CD66a,  C-CAM,  mCEA1,  mmCGM2,  mmCGM1

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ceacam1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ceacam1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cystic Fibrosis
Gastroesophageal reflux, Recurrent respiratory infections, Recurrent Aspergillus infections, Recu... ORPHA:586

The table below shows human diseases predicted to be associated to Ceacam1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ciliary Discoordination Due To Random Ciliary Orientation
Recurrent infections OMIM:215518
Appendicitis, Proneness To
Abnormal large intestine morphology OMIM:107700
Axin2-Related Attenuated Familial Adenomatous Polyposis
Colon cancer, Neoplasm of the rectum, Colorectal polyposis, Adenomatous colonic polyposis ORPHA:401911
Hirschsprung Disease, Susceptibility To, 3
Aganglionic megacolon, Total colonic aganglionosis, Long-segment aganglionic megacolon OMIM:613711
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome
Gastrointestinal hemorrhage, Abnormal large intestine morphology, Gastroesophageal reflux, Abnorm... ORPHA:2198
Muir-Torre Syndrome
Sebaceous gland carcinoma, Colonic diverticula, Colon cancer, Malignant genitourinary tract tumor... OMIM:158320
Squamous Cell Carcinoma Of The Anal Canal
Anal stenosis, Intestinal bleeding, Neoplasm of the skeletal system, Neoplasm of the liver, Neopl... ORPHA:424019
Visceral Myopathy 2
Barrett esophagus, Gastroesophageal reflux, Volvulus, Intestinal pseudo-obstruction, Intestinal m... OMIM:619350
Neuroblastoma, Susceptibility To, 2
Aganglionic megacolon, Ganglioneuroma, Ganglioneuroblastoma, Neuroblastoma OMIM:613013
Nk-Cell Enteropathy
Hematochezia, Colonic diverticula, Gastroesophageal reflux, Stercoral ulcer, Abnormal gastric muc... ORPHA:263665
Meconium Ileus
Microcolon, Meconium ileus OMIM:614665
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome
Microcolon, Sepsis, Intestinal malrotation, Neoplasm of the heart, Abnormality of the gastrointes... ORPHA:2241
Gist-Plus Syndrome
Gastrointestinal stroma tumor, Intestinal polyposis, Intussusception OMIM:175510
Radiation Proctitis
Hematochezia, Sepsis, Abnormal rectum morphology, Intestinal obstruction, Rectal fistula, Abnorma... ORPHA:70475
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 3
Microcolon, Sepsis OMIM:619362
Visceral Myopathy 1
Microcolon, Intestinal pseudo-obstruction, Megaduodenum, Thinning of outer muscular layer of smal... OMIM:155310
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 5
Intestinal malrotation, Microcolon OMIM:619431
Bannayan-Riley-Ruvalcaba Syndrome
Uterine neoplasm, Abnormal large intestine morphology, Lymphoma, Capillary hemangioma, Meningioma... ORPHA:109
Mednik Syndrome
Microcolon, Volvulus, Jejunal atresia OMIM:609313
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Microcolon, Recurrent infections, Ileal atresia OMIM:619351
Fg Syndrome Type 1
Abnormal large intestine morphology, Gastroesophageal reflux, Anal atresia, High palate, Malrotat... ORPHA:93932
Systemic Sclerosis
Barrett esophagus, Intestinal bleeding, Abnormal large intestine morphology, Gastroesophageal ref... ORPHA:90291
Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Waardenburg Syndrome-Hirschsprung Disease
Aganglionic megacolon, Microcolon, Ileus ORPHA:163746
Cystic Fibrosis
Gastroesophageal reflux, Recurrent respiratory infections, Recurrent Aspergillus infections, Recu... ORPHA:586
Heart Defects, Congenital, And Other Congenital Anomalies
Colon perforation, Microcolon, Intestinal malrotation OMIM:600001
Restrictive Dermopathy
Microcolon, Submucous cleft hard palate ORPHA:1662

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ceacam1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ceacam1.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Ceacam11em1(IMPC)Wtsi Ceacam12em1(IMPC)Wtsi Ceacam13em1(IMPC)Wtsi Ceacam14em1(IMPC)Wtsi Ceacam15em1(IMPC)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Ceacam11em1(IMPC)Wtsi Ceacam12em1(IMPC)Wtsi Ceacam13em1(IMPC)Wtsi Ceacam14em1(IMPC)Wtsi Ceacam15em1(IMPC)Wtsi Ceacam15em1(IMPC)Wtsi PMC6671969
Accelerated Age-Related Degradation of the Tectorial Membrane in the Ceacam16βgal/βgal Null Mutant Mouse, a Model for Late-Onset Human Hereditary Deafness DFNB113. Frontiers in molecular neuroscience (June 2019) Ceacam16tm1(KOMP)Wtsi PMC6582249
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PloS one (July 2017) Ceacam16tm1.1(KOMP)Wtsi PMC5503261
Loss of the tectorial membrane protein CEACAM16 enhances spontaneous, stimulus-frequency, and transiently evoked otoacoustic emissions. The Journal of neuroscience : the official journal of the Society for Neuroscience (July 2014) Ceacam16tm1(KOMP)Wtsi PMC4115139

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MGI Allele Allele Type Produced
Ceacam1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ceacam1tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ceacam1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ceacam1tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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