Fto | FTO alpha-ketoglutarate dependent dioxygenase

GeneMGI:1347093

Physiological systems

20 / 24 physiological systems tested

1 Significantly impacted by the knock-out

Homeostasis/metabolism

19 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

3Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes



decreased circulating alanine transaminase level	1 supporting dataset	Fto^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.76x10^-6
decreased circulating cholesterol level	1 supporting dataset	Fto^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.09x10^-5
decreased circulating iron level	1 supporting dataset	Fto^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.21x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fto.

Associated images

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Histopathology

There is no histopathology data found for Fto.

IMPC related publications

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External links

No external links available for Fto.

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*Fto^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Fto^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Fto^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Fto^{tm2(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell

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