Abcg2 | ATP binding cassette subfamily G member 2 (Junior blood group)
Physiological systems
17 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye
15 No significant impact
7 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:49Adult tissues
50Embryo tissues
| fused cornea and lens | 1 supporting dataset | Abcg2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 7.42x10-5 | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Abcg2tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.67x10-5 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Abcg2tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.62x10-6 | ||
| increased circulating cholesterol level | 1 supporting dataset | Abcg2tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.46x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Abcg2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Abcg2.
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| Abcg2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Abcg2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Abcg2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Abcg2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |