Map3k10 | mitogen-activated protein kinase kinase kinase 10
Physiological systems
18 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Homeostasis/metabolism
17 No significant impact
6 Not tested
Data collections
Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| increased circulating cholesterol level | 1 supporting dataset | Map3k10tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.38x10-5 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Map3k10tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.79x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Wholemount images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Map3k10 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Map3k10.
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| Map3k10tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Map3k10tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Map3k10tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Map3k10tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |