Map3k1 | mitogen-activated protein kinase kinase kinase 1

GeneMGI:1346872Synonyms: Mekk, MEKK1

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



decreased circulating fructosamine level	1 supporting dataset	Map3k1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	5.16x10^-6
abnormal startle reflex	1 supporting dataset	Map3k1^{Gt(YTC001)Byg}	heterozygote	Early adult	5.41x10^-5
increased red blood cell distribution width	1 supporting dataset	Map3k1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	6.4x10^-5
decreased fasting circulating glucose level	1 supporting dataset	Map3k1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	5.76x10^-6
increased circulating free fatty acids level	1 supporting dataset	Map3k1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.52x10^-5
increased lean body mass	1 supporting dataset	Map3k1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	9.82x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Map3k1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Map3k1^{Gt(YTC001)Byg}	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Map3k1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	4.58x10^-5
increased bone mineral content	1 supporting dataset	Map3k1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	4.84x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Map3k1.

Associated images

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Histopathology

There is no histopathology data found for Map3k1.

IMPC related publications

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External links

No external links available for Map3k1.

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*Map3k1^{Gt(YTC001)Byg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Map3k1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Map3k1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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