Esrra | estrogen related receptor, alpha
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Cardiovascular system
14 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
46Embryo tissues
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Esrratm1.1(KOMP)Vlcg | homozygote | Early adult | 6.28x10-5 | ||
| decreased vertical activity | 1 supporting dataset | Esrratm1.1(KOMP)Vlcg | homozygote | Early adult | 2.42x10-6 | ||
| hyperactivity | 1 supporting dataset | Esrratm1.1(KOMP)Vlcg | homozygote | Early adult | 4.77x10-5 | ||
| shortened PQ interval | 1 supporting dataset | Esrratm1.1(KOMP)Vlcg | homozygote | Early adult | 3.64x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Esrratm1.1(KOMP)Vlcg | homozygote | Early adult | 3.26x10-11 | ||
| increased grip strength | 2 supporting datasets | Esrratm1.1(KOMP)Vlcg | homozygote | Early adult | 5.02x10-6 | ||
| increased startle reflex | 1 supporting dataset | Esrratm1.1(KOMP)Vlcg | homozygote | Early adult | 2.21x10-5 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Esrra mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Esrra.
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| Esrratm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Esrratm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Esrratm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Esrratm457105(L1L2_GT1_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |