Insl5 | insulin-like 5

GeneMGI:1346085Synonyms: relaxin/insulin-like factor 2, RIF2

Physiological systems

11 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Respiratory system Behavior/neurological

8 No significant impact

13 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased exploration in new environment1 supporting datasetInsl5Insl5homozygoteEarly adult2.48x10-5 
hyporesponsive to tactile stimuli1 supporting datasetInsl5Insl5homozygoteEarly adult2.47x10-5 
increased blood uric acid level1 supporting datasetInsl5Insl5homozygoteEarly adult8.99x10-7 
abnormal anxiety-related response1 supporting datasetInsl5Insl5homozygoteEarly adult2.69x10-9 
decreased vertical activity1 supporting datasetInsl5Insl5homozygoteEarly adult5.74x10-5 
abnormal whole-body plethysmography1 supporting datasetInsl5Insl5homozygoteEarly adult8.55x10-5 
abnormal iron homeostasis1 supporting datasetInsl5Insl5homozygoteEarly adult3.94x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Insl5tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Insl5tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Insl5tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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