Tlk2 | tousled-like kinase 2 (Arabidopsis)
Physiological systems
16 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Embryo Skeleton Mortality/aging
13 No significant impact
8 Not tested
Data collections
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal bone structure | 1 supporting dataset | Tlk2em1(IMPC)Bay | heterozygote | Early adult | 9.39x10-9 | ||
| abnormal embryo turning | 1 supporting dataset | Tlk2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| increased bone mineral content | 2 supporting datasets | Tlk2em1(IMPC)Bay | heterozygote | Early adult | 3.37x10-9 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Tlk2em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Tlk2em1(IMPC)Bay | homozygote | E15.5 | N/A * |
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Human diseases caused by Tlk2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tlk2.
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| Tlk2em1(IMPC)Bay | Exon Deletion | | mouse |
| Tlk2tm181271(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Tlk2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |