Slc25a1 | solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1

GeneMGI:1345283Synonyms: 2610100G11Rik, Dgsj, +2 more

Physiological systems

21 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Integument Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Craniofacial Cardiovascular system Homeostasis/metabolism Embryo Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging

7 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:25Significant phenotypes

4Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



abnormal forebrain morphology	1 supporting dataset	Slc25a1^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
no spontaneous movement	1 supporting dataset	Slc25a1^{em1(IMPC)Kmpc}	heterozygote	E18.5	N/A ^*
abnormal embryo size	1 supporting dataset	Slc25a1^{tm1b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Slc25a1^{tm1b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
abnormal embryo development	1 supporting dataset	Slc25a1^{tm1b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
increased exploration in new environment	1 supporting dataset	Slc25a1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.94x10^-5
abnormal tail morphology	1 supporting dataset	Slc25a1^{em1(IMPC)Kmpc}	homozygote	E12.5	N/A ^*
no spontaneous movement	1 supporting dataset	Slc25a1^{em1(IMPC)Kmpc}	homozygote	E18.5	N/A ^*
exencephaly	1 supporting dataset	Slc25a1^{tm1b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
facial cleft	1 supporting dataset	Slc25a1^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Slc25a1.

Associated images

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Histopathology

There is no histopathology data found for Slc25a1.

IMPC related publications

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External links

No external links available for Slc25a1.

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*Slc25a1^{em1(IMPC)Kmpc}*	Deletion	‌	mouse
*Slc25a1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Slc25a1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Slc25a1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Slc25a1^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Slc25a1^{tm45102(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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