Pacsin2 | protein kinase C and casein kinase substrate in neurons 2

GeneMGI:1345153Synonyms: Syndapin II

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hearing/vestibular/ear Hematopoietic system Cardiovascular system

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



decreased hematocrit	1 supporting dataset	Pacsin2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.44x10^-5
decreased mean corpuscular volume	1 supporting dataset	Pacsin2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.11x10^-26
increased fasting circulating glucose level	1 supporting dataset	Pacsin2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.8x10^-7
abnormal auditory brainstem response	1 supporting dataset	Pacsin2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.9x10^-5
thrombocytosis	1 supporting dataset	Pacsin2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.8x10^-5
decreased mean corpuscular hemoglobin	1 supporting dataset	Pacsin2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.16x10^-80
increased lean body mass	1 supporting dataset	Pacsin2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.31x10^-5
increased heart weight	1 supporting dataset	Pacsin2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.75x10^-5
decreased hemoglobin content	1 supporting dataset	Pacsin2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.2x10^-8
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Pacsin2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.79x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pacsin2.

Associated images

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Histopathology

There is no histopathology data found for Pacsin2.

IMPC related publications

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External links

No external links available for Pacsin2.

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*Pacsin2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pacsin2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pacsin2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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