Pde10a | phosphodiesterase 10A

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Hematopoietic system Behavior/neurological

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:4Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased locomotor activity5 supporting datasetsPde10aem1(IMPC)HhomozygoteEarly adult9.33x10-6 
increased circulating iron level1 supporting datasetPde10aem1(IMPC)HhomozygoteEarly adult3.49x10-5 
increased mean corpuscular volume1 supporting datasetPde10aem1(IMPC)HhomozygoteEarly adult2.92x10-5 
increased mean platelet volume1 supporting datasetPde10aem1(IMPC)HhomozygoteEarly adult9.68x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pde10aem1(IMPC)HExon Deletionmouse
Pde10atm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Pde10atm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Pde10atm2e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Pde10atm40541(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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