Aloxe3 | arachidonate lipoxygenase 3

GeneMGI:1345140Synonyms: e-LOX-3

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Immune system Embryo Growth/size/body region Vision/eye Hematopoietic system Mortality/aging Cardiovascular system

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Aloxe3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Aloxe3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
microphthalmia	1 supporting dataset	Aloxe3^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Aloxe3^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Aloxe3^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Aloxe3^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
enlarged lymph nodes	1 supporting dataset	Aloxe3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal blood vessel morphology	1 supporting dataset	Aloxe3^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Aloxe3^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
small spleen	1 supporting dataset	Aloxe3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aloxe3.

Associated images

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Histopathology

There is no histopathology data found for Aloxe3.

IMPC related publications

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External links

No external links available for Aloxe3.

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*Aloxe3^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Aloxe3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Aloxe3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Aloxe3^{tm299258(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Aloxe3^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Aloxe3^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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