Ubd | ubiquitin D
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Hematopoietic system Behavior/neurological
16 No significant impact
3 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:78Adult tissues
36Embryo tissues
| abnormal seminal vesicle morphology | 1 supporting dataset | Ubdtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| small thymus | 1 supporting dataset | Ubdtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased CD4-positive, CD25-positive NK T cell number | 1 supporting dataset | Ubdtm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.73x10-6 | ||
| decreased memory-marker CD4-positive NK T cell number | 1 supporting dataset | Ubdtm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.1x10-9 | ||
| abnormal thymus morphology | 1 supporting dataset | Ubdtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| impaired contextual conditioning behavior | 1 supporting dataset | Ubdtm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.24x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 50% (1/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | n/a | 0% (0/17) |
| bone | heterozygote | Section images | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | n/a | 0% (0/22) |
| brain | heterozygote | Section images | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | Section images | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Ubd mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ubd.
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| Ubdtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ubdtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ubdtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ubdtm1c(EUCOMM)Wtsi | Wild type floxed exon (post-Flp) | | mouse |