Arih2 | ariadne RBR E3 ubiquitin protein ligase 2
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Integument Embryo Growth/size/body region Mortality/aging Renal/urinary system
15 No significant impact
4 Not tested
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
30Embryo tissues
| embryonic growth retardation | 1 supporting dataset | Arih2tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Arih2tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Arih2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| cystolithiasis | 1 supporting dataset | Arih2tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Arih2tm1.1(KOMP)Vlcg | heterozygote | E9.5 | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Arih2tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Arih2tm1.1(KOMP)Vlcg | heterozygote | E9.5 | N/A * | ||
| abnormal urinary bladder morphology | 1 supporting dataset | Arih2tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Arih2tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| polycystic kidney | 1 supporting dataset | Arih2tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 50% (2/4) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 50% (2/4) | 0.19% (1/533) |
| blood | heterozygote | Section images | 100% (2/2) | 0% (0/17) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | n/a | 50% (2/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (4/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 50% (2/4) | 0.56% (3/532) |
Human diseases caused by Arih2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Arih2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Arih2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Arih2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Arih2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Arih2tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Arih2tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |