Arpc1b | actin related protein 2/3 complex, subunit 1B

GeneMGI:1343142Synonyms: SOP2Hs, p41-ARC, +1 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Skeleton

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:38Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	1 supporting dataset	Arpc1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased memory-marker CD4-negative NK T cell number	2 supporting datasets	Arpc1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Arpc1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.73x10^-5
increased circulating total protein level	1 supporting dataset	Arpc1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.54x10^-6
increased KLRG1+ CD4 alpha-beta T cell number	2 supporting datasets	Arpc1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased mature NK cell number	2 supporting datasets	Arpc1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased CD4-positive, alpha-beta memory T cell number	2 supporting datasets	Arpc1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased memory-marker NK cell number	1 supporting dataset	Arpc1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased plasma cell number	2 supporting datasets	Arpc1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased transitional stage T2 B cell number	2 supporting datasets	Arpc1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arpc1b.

Associated images

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Histopathology

There is no histopathology data found for Arpc1b.

IMPC related publications

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External links

No external links available for Arpc1b.

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*Arpc1b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Arpc1b^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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