Asap1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain1

GeneMGI:1342335Synonyms: Ddef1

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Hearing/vestibular/ear Mortality/aging Cardiovascular system

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal auditory brainstem response	1 supporting dataset	Asap1^{em1(IMPC)Wtsi}	heterozygote	Early adult	9.85x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Asap1^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*
decreased heart rate	1 supporting dataset	Asap1^{em1(IMPC)Wtsi}	homozygote	Early adult	2.21x10^-8
prolonged RR interval	1 supporting dataset	Asap1^{em1(IMPC)Wtsi}	homozygote	Early adult	1.64x10^-19

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Asap1.

Associated images

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Histopathology

There is no histopathology data found for Asap1.

IMPC related publications

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External links

No external links available for Asap1.

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*Asap1^{em1(IMPC)Wtsi}*	Exon Deletion	‌	mouse
*Asap1^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Asap1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Asap1^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	es cell
*Asap1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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