Gsto1 | glutathione S-transferase omega 1
Physiological systems
17 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Pigmentation Integument Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton
10 No significant impact
7 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal coat/hair pigmentation | 3 supporting datasets | Gsto1em1(IMPC)J | homozygote | Late adult | 8.21x10-8 | ||
| abnormal locomotor behavior | 1 supporting dataset | Gsto1em1(IMPC)J | homozygote | Late adult | 4.72x10-6 | ||
| abnormal coat appearance | 1 supporting dataset | Gsto1em1(IMPC)J | homozygote | Late adult | 1.89x10-7 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Gsto1em1(IMPC)J | homozygote | Early adult | 4.08x10-5 | ||
| decreased lean body mass | 1 supporting dataset | Gsto1em1(IMPC)J | homozygote | Late adult | 7.25x10-5 | ||
| abnormal coat/ hair morphology | 1 supporting dataset | Gsto1em1(IMPC)J | homozygote | Late adult | 2.62x10-6 | ||
| increased startle reflex | 1 supporting dataset | Gsto1em1(IMPC)J | homozygote | Early adult | 2.75x10-5 | ||
| decreased bone mineral content | 1 supporting dataset | Gsto1em1(IMPC)J | homozygote | Late adult | 1.6x10-6 | ||
| increased total body fat amount | 1 supporting dataset | Gsto1em1(IMPC)J | homozygote | Late adult | 3.45x10-5 |
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Human diseases caused by Gsto1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gsto1.
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| Gsto1em1(IMPC)J | Exon Deletion | | mouse |
| Gsto1tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Gsto1tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |