Eif4h | eukaryotic translation initiation factor 4H
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Embryo Growth/size/body region Vision/eye Mortality/aging Cardiovascular system
16 No significant impact
3 Not tested
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| decreased total retina thickness | 2 supporting datasets | Eif4htm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.12x10-13 | ||
| abnormal retina inner nuclear layer morphology | 2 supporting datasets | Eif4htm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.42x10-7 | ||
| embryonic growth retardation | 1 supporting dataset | Eif4htm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Eif4htm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal retina outer nuclear layer morphology | 1 supporting dataset | Eif4htm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.71x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Eif4htm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Eif4htm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| thin ventricular wall | 1 supporting dataset | Eif4htm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.65x10-7 |
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External links
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| Eif4htm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Eif4htm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Eif4htm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |