Eif4h | eukaryotic translation initiation factor 4H
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Embryo Growth/size/body region Vision/eye Mortality/aging Cardiovascular system
16 No significant impact
3 Not tested
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| decreased total retina thickness | 2 supporting datasets | Eif4htm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.12x10-13 | ||
| abnormal retina inner nuclear layer morphology | 2 supporting datasets | Eif4htm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.42x10-7 | ||
| embryonic growth retardation | 1 supporting dataset | Eif4htm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Eif4htm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal retina outer nuclear layer morphology | 1 supporting dataset | Eif4htm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.71x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Eif4htm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Eif4htm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| thin ventricular wall | 1 supporting dataset | Eif4htm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.65x10-7 |
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| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Wholemount images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 100% (1/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Eif4h mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Eif4h.
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| Eif4htm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Eif4htm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Eif4htm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |