Lgr5 | leucine rich repeat containing G protein coupled receptor 5
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Immune system Growth/size/body region Digestive/alimentary Hematopoietic system Behavior/neurological Mortality/aging Craniofacial
12 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | homozygote | Early adult | N/A * | ||
| no spontaneous movement | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | heterozygote | E18.5 | N/A * | ||
| cleft palate | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | homozygote | E18.5 | N/A * | ||
| increased CD11b-high dendritic cell number | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | heterozygote | Early adult | 3.69x10-6 | ||
| no spontaneous movement | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | homozygote | E18.5 | N/A * | ||
| increased grip strength | 3 supporting datasets | Lgr5em1(IMPC)Kmpc | heterozygote | Early adult | 9.12x10-6 | ||
| increased CD8-positive, CD25-positive alpha-beta T cell number | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | heterozygote | Early adult | 1.31x10-5 |
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Human diseases caused by Lgr5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Lgr5.
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| Lgr5em1(IMPC)Kmpc | Deletion | | mouse |
| Lgr5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Lgr5tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Lgr5tm374781(L1L2_GT2_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |