Pla2g2d | phospholipase A2, group IID

GeneMGI:1341796Synonyms: Splash, mGIID

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Renal/urinary system

13 No significant impact

6 Not tested

Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
46Embryo tissues

Phenotypes

decreased urine magnesium level1 supporting datasetPla2g2dtm1.1(KOMP)VlcghomozygoteEarly adult4.4x10-5 
hyperactivity1 supporting datasetPla2g2dtm1.1(KOMP)VlcghomozygoteEarly adult2.21x10-5 
decreased leukocyte cell number1 supporting datasetPla2g2dtm1.1(KOMP)VlcghomozygoteEarly adult4.74x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
brainheterozygoteSection images
100% (2/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
epididymisheterozygoten/a0% (0/1)87.5% (21/24)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Pla2g2dtm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Pla2g2dtm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Pla2g2dtm373680(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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