Aqp6 | aquaporin 6
GeneMGI:1341204
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Renal/urinary system
16 No significant impact
5 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| increased circulating chloride level | 1 supporting dataset | Aqp6tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.09x10-5 | ||
| abnormal kidney morphology | 1 supporting dataset | Aqp6tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased total retina thickness | 1 supporting dataset | Aqp6tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.37x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | Wholemount images | 100% (2/2) | 7.75% (22/284) |
Human diseases caused by Aqp6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Aqp6.
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| Aqp6tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Aqp6tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Aqp6tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |