Tnks | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

GeneMGI:1341087Synonyms: Parp5a, mTNKS1, +4 more

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:22Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased total body fat amount1 supporting datasetTnksem1(IMPC)HmguhomozygoteEarly adult1.22x10-5 
increased fasting circulating glucose level1 supporting datasetTnksem1(IMPC)HmguhomozygoteEarly adult1.3x10-8 
increased mean platelet volume1 supporting datasetTnksem1(IMPC)HmguhomozygoteEarly adult2.98x10-6 
increased circulating alkaline phosphatase level1 supporting datasetTnksem1(IMPC)HmguhomozygoteEarly adult1.7x10-6 
increased heart weight1 supporting datasetTnksem1(IMPC)HmguhomozygoteEarly adult8.37x10-5 
increased circulating bilirubin level1 supporting datasetTnksem1(IMPC)HmguhomozygoteEarly adult1.33x10-8 
abnormal bone structure1 supporting datasetTnksem1(IMPC)HmguhomozygoteEarly adult8.95x10-6 
decreased circulating glucose level1 supporting datasetTnksem1(IMPC)HmguhomozygoteEarly adult1.04x10-5 
thrombocytopenia1 supporting datasetTnksem1(IMPC)HmguhomozygoteEarly adult1.74x10-10 
decreased circulating triglyceride level1 supporting datasetTnksem1(IMPC)HmguhomozygoteEarly adult2.02x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tnksem1(IMPC)HmguExon Deletionmouse
Tnkstm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Tnkstm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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