Tnks | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Physiological systems
20 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
11 No significant impact
4 Not tested
Data collections
Gene metrics:22Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
decreased total body fat amount | 1 supporting dataset | Tnksem1(IMPC)Hmgu | homozygote | Early adult | 1.22x10-5 | ||
increased fasting circulating glucose level | 1 supporting dataset | Tnksem1(IMPC)Hmgu | homozygote | Early adult | 1.3x10-8 | ||
increased mean platelet volume | 1 supporting dataset | Tnksem1(IMPC)Hmgu | homozygote | Early adult | 2.98x10-6 | ||
increased circulating alkaline phosphatase level | 1 supporting dataset | Tnksem1(IMPC)Hmgu | homozygote | Early adult | 1.7x10-6 | ||
increased heart weight | 1 supporting dataset | Tnksem1(IMPC)Hmgu | homozygote | Early adult | 8.37x10-5 | ||
increased circulating bilirubin level | 1 supporting dataset | Tnksem1(IMPC)Hmgu | homozygote | Early adult | 1.33x10-8 | ||
abnormal bone structure | 1 supporting dataset | Tnksem1(IMPC)Hmgu | homozygote | Early adult | 8.95x10-6 | ||
decreased circulating glucose level | 1 supporting dataset | Tnksem1(IMPC)Hmgu | homozygote | Early adult | 1.04x10-5 | ||
thrombocytopenia | 1 supporting dataset | Tnksem1(IMPC)Hmgu | homozygote | Early adult | 1.74x10-10 | ||
decreased circulating triglyceride level | 1 supporting dataset | Tnksem1(IMPC)Hmgu | homozygote | Early adult | 2.02x10-5 |
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External links
No external links available for Tnks.
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Tnksem1(IMPC)Hmgu | Exon Deletion | | mouse |
Tnkstm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell |
Tnkstm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | es cell |