Pak1 | p21 (RAC1) activated kinase 1
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Nervous system Skeleton
14 No significant impact
6 Not tested
Data collections
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| increased circulating triglyceride level | 1 supporting dataset | Pak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.26x10-8 | ||
| increased blood urea nitrogen level | 1 supporting dataset | Pak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.45x10-8 | ||
| decreased bone mineral content | 1 supporting dataset | Pak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.02x10-5 | ||
| increased total body fat amount | 1 supporting dataset | Pak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.12x10-5 | ||
| decreased prepulse inhibition | 1 supporting dataset | Pak1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.99x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Pak1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pak1.
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| Pak1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pak1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pak1tm1c(EUCOMM)Hmgu | Wild type floxed exon (post-Flp) | | mouse |
| Pak1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |