Smc3 | structural maintenance of chromosomes 3

GeneMGI:1339795Synonyms: SmcD, Bamacan, +2 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Pigmentation Integument Growth/size/body region Craniofacial Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased body weight	4 supporting datasets	Smc3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.41x10^-11
abnormal coat/hair pigmentation	1 supporting dataset	Smc3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.64x10^-6
abnormal snout morphology	1 supporting dataset	Smc3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.24x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Smc3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Smc3.

Associated images

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Histopathology

There is no histopathology data found for Smc3.

IMPC related publications

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External links

No external links available for Smc3.

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*Smc3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Smc3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse

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