Smc3 | structural maintenance of chromosomes 3
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Pigmentation Integument Growth/size/body region Craniofacial Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased body weight | 4 supporting datasets | Smc3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.41x10-11 | ||
| abnormal coat/hair pigmentation | 1 supporting dataset | Smc3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.64x10-6 | ||
| abnormal snout morphology | 1 supporting dataset | Smc3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.24x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Smc3tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Smc3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Smc3.
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| Smc3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Smc3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |