Myh1 | myosin, heavy polypeptide 1, skeletal muscle, adult

GeneMGI:1339711Synonyms: Myhs-f2, Myhs-f, +7 more

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Nervous system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Renal/urinary system

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



decreased prepulse inhibition	4 supporting datasets	Myh1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.04x10^-8
abnormal sleep behavior	4 supporting datasets	Myh1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.45x10^-14
increased hemoglobin content	1 supporting dataset	Myh1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.39x10^-5
decreased grip strength	4 supporting datasets	Myh1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.03x10^-14
abnormal auditory brainstem response	4 supporting datasets	Myh1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.63x10^-8
decreased thigmotaxis	4 supporting datasets	Myh1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.01x10^-8
decreased urine creatinine level	1 supporting dataset	Myh1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.08x10^-33
decreased urine magnesium level	1 supporting dataset	Myh1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.72x10^-42
decreased leukocyte cell number	1 supporting dataset	Myh1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.69x10^-7
decreased bone mineral content	2 supporting datasets	Myh1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.46x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Myh1.

Associated images

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Histopathology

There is no histopathology data found for Myh1.

IMPC related publications

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External links

No external links available for Myh1.

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*Myh1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Myh1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Myh1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Myh1^{tm2(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Myh1^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Myh1^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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