Myh1 | myosin, heavy polypeptide 1, skeletal muscle, adult
Physiological systems
18 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Nervous system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Renal/urinary system
9 No significant impact
6 Not tested
Data collections
Gene metrics:18Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| decreased prepulse inhibition | 4 supporting datasets | Myh1tm1b(KOMP)Wtsi | homozygote | Early adult | 1.04x10-8 | ||
| abnormal sleep behavior | 4 supporting datasets | Myh1tm1b(KOMP)Wtsi | homozygote | Early adult | 1.45x10-14 | ||
| increased hemoglobin content | 1 supporting dataset | Myh1tm1b(KOMP)Wtsi | homozygote | Early adult | 3.39x10-5 | ||
| decreased grip strength | 4 supporting datasets | Myh1tm1b(KOMP)Wtsi | homozygote | Early adult | 1.03x10-14 | ||
| abnormal auditory brainstem response | 4 supporting datasets | Myh1tm1b(KOMP)Wtsi | homozygote | Early adult | 2.63x10-8 | ||
| decreased thigmotaxis | 4 supporting datasets | Myh1tm1b(KOMP)Wtsi | homozygote | Early adult | 3.01x10-8 | ||
| decreased urine creatinine level | 1 supporting dataset | Myh1tm1b(KOMP)Wtsi | homozygote | Early adult | 1.08x10-33 | ||
| decreased urine magnesium level | 1 supporting dataset | Myh1tm1b(KOMP)Wtsi | homozygote | Early adult | 6.72x10-42 | ||
| decreased leukocyte cell number | 1 supporting dataset | Myh1tm1b(KOMP)Wtsi | homozygote | Early adult | 4.69x10-7 | ||
| decreased bone mineral content | 2 supporting datasets | Myh1tm1b(KOMP)Wtsi | homozygote | Early adult | 1.46x10-10 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/1) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Myh1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Myh1.
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| Myh1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Myh1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Myh1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Myh1tm2(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Myh1tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Myh1tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |