Gfpt2 | glutamine fructose-6-phosphate transaminase 2
Physiological systems
19 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial Cardiovascular system
11 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased red blood cell distribution width | 1 supporting dataset | Gfpt2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.23x10-8 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Gfpt2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.45x10-9 | ||
| abnormal tooth morphology | 1 supporting dataset | Gfpt2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.88x10-9 | ||
| abnormal vocalization | 1 supporting dataset | Gfpt2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.28x10-5 | ||
| abnormal lens morphology | 2 supporting datasets | Gfpt2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.05x10-7 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Gfpt2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.41x10-7 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Gfpt2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.28x10-5 |
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Human diseases caused by Gfpt2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gfpt2.
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| Gfpt2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Gfpt2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gfpt2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Gfpt2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |