Gfpt2 | glutamine fructose-6-phosphate transaminase 2

GeneMGI:1338883Synonyms: GFAT2

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial Cardiovascular system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased red blood cell distribution width	1 supporting dataset	Gfpt2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.23x10^-8
increased fasting circulating glucose level	1 supporting dataset	Gfpt2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.45x10^-9
abnormal tooth morphology	1 supporting dataset	Gfpt2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.88x10^-9
abnormal vocalization	1 supporting dataset	Gfpt2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.28x10^-5
abnormal lens morphology	2 supporting datasets	Gfpt2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.05x10^-7
abnormal retina vasculature morphology	1 supporting dataset	Gfpt2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.41x10^-7
decreased circulating serum albumin level	1 supporting dataset	Gfpt2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.28x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gfpt2.

Associated images

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Histopathology

There is no histopathology data found for Gfpt2.

IMPC related publications

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External links

No external links available for Gfpt2.

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*Gfpt2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Gfpt2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Gfpt2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Gfpt2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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