Aire | autoimmune regulator
GeneMGI:1338803
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Nervous system Vision/eye Hematopoietic system
12 No significant impact
7 Not tested
Data collections
Gene metrics:8Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal eye morphology | 2 supporting datasets | Airetm1.1(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| increased monocyte cell number | 1 supporting dataset | Airetm1.1(NCOM)Mfgc | homozygote | Early adult | 7.59x10-5 | ||
| decreased prepulse inhibition | 2 supporting datasets | Airetm1.1(NCOM)Mfgc | homozygote | Early adult | 1.53x10-5 | ||
| abnormal cholesterol homeostasis | 1 supporting dataset | Airetm1.1(NCOM)Mfgc | heterozygote | Early adult | 1.28x10-9 | ||
| abnormal retina morphology | 1 supporting dataset | Airetm1.1(NCOM)Mfgc | homozygote | Early adult | 4.67x10-6 |
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Human diseases caused by Aire mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Aire.
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| Airetm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |
| Airetm1.1(NCOM)Mfgc | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Airetm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Airetm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |