Aire | autoimmune regulator
GeneMGI:1338803
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Nervous system Vision/eye Hematopoietic system
12 No significant impact
7 Not tested
Data collections
Gene metrics:8Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal eye morphology | 2 supporting datasets | Airetm1.1(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| increased monocyte cell number | 1 supporting dataset | Airetm1.1(NCOM)Mfgc | homozygote | Early adult | 7.59x10-5 | ||
| decreased prepulse inhibition | 2 supporting datasets | Airetm1.1(NCOM)Mfgc | homozygote | Early adult | 1.53x10-5 | ||
| abnormal cholesterol homeostasis | 1 supporting dataset | Airetm1.1(NCOM)Mfgc | heterozygote | Early adult | 1.28x10-9 | ||
| abnormal retina morphology | 1 supporting dataset | Airetm1.1(NCOM)Mfgc | homozygote | Early adult | 4.67x10-6 |
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External links
No external links available for Aire.
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| Airetm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |
| Airetm1.1(NCOM)Mfgc | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Airetm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Airetm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |