Itsn1 | intersectin 1 (SH3 domain protein 1A)

GeneMGI:1338069Synonyms: Sh3p17, EHSH1, +3 more

Physiological systems

16 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Nervous system Behavior/neurological

12 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating amylase level	1 supporting dataset	Itsn1^em1(IMPC)H	homozygote	Early adult	2.81x10^-8
increased circulating iron level	1 supporting dataset	Itsn1^em1(IMPC)H	homozygote	Early adult	2.67x10^-11
increased circulating total protein level	1 supporting dataset	Itsn1^em1(IMPC)H	homozygote	Early adult	2.31x10^-5
abnormal gait	1 supporting dataset	Itsn1^em1(IMPC)H	homozygote	Early adult	1.26x10^-5
decreased exploration in new environment	1 supporting dataset	Itsn1^em1(IMPC)H	heterozygote	Early adult	6.08x10^-7
abnormal skin coloration	2 supporting datasets	Itsn1^em1(IMPC)H	homozygote	Early adult	2.76x10^-11
increased circulating alkaline phosphatase level	1 supporting dataset	Itsn1^em1(IMPC)H	homozygote	Early adult	2x10^-17
limb grasping	1 supporting dataset	Itsn1^em1(IMPC)H	homozygote	Early adult	1.04x10^-8
decreased prepulse inhibition	1 supporting dataset	Itsn1^em1(IMPC)H	homozygote	Early adult	2.57x10^-5
increased circulating serum albumin level	1 supporting dataset	Itsn1^em1(IMPC)H	homozygote	Early adult	6.26x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Itsn1.

Associated images

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Histopathology

There is no histopathology data found for Itsn1.

IMPC related publications

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External links

No external links available for Itsn1.

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*Itsn1^em1(IMPC)H*	Exon Deletion	‌	mouse
*Itsn1^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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