Gdf11 | growth differentiation factor 11
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Growth/size/body region Digestive/alimentary Limbs/digits/tail Vision/eye Mortality/aging Craniofacial Cardiovascular system
14 No significant impact
3 Not tested
Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Gdf11tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| cleft palate | 1 supporting dataset | Gdf11tm2b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
| abnormal facial morphology | 1 supporting dataset | Gdf11tm2b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| abnormal tail morphology | 1 supporting dataset | Gdf11tm2b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
| abnormal craniofacial morphology | 1 supporting dataset | Gdf11tm2b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| abnormal tail morphology | 1 supporting dataset | Gdf11tm2b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Gdf11tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 4.83x10-5 | ||
| increased cardiac stroke volume | 1 supporting dataset | Gdf11tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 2.61x10-6 |
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External links
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| Gdf11tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gdf11tm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Gdf11tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |