Klhl22 | kelch-like 22
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Growth/size/body region Vision/eye Behavior/neurological
14 No significant impact
7 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased lean body mass | 1 supporting dataset | Klhl22em1(IMPC)J | homozygote | Late adult | 1.02x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Klhl22em1(IMPC)J | homozygote | Late adult | 2.51x10-6 | ||
| decreased locomotor activity | 1 supporting dataset | Klhl22em1(IMPC)J | homozygote | Late adult | 1.85x10-5 |
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Human diseases caused by Klhl22 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Klhl22.
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| Klhl22em1(IMPC)J | Exon Deletion | | mouse |
| Klhl22tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |