Serf1 | small EDRK-rich factor 1
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Skeleton Cardiovascular system
13 No significant impact
5 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating cholesterol level | 1 supporting dataset | Serf1tm1a(EUCOMM)Hmgu | homozygote | Early adult | 5.6x10-12 | ||
| decreased bone mineral density | 1 supporting dataset | Serf1tm1a(EUCOMM)Hmgu | homozygote | Early adult | 2.2x10-5 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Serf1tm1a(EUCOMM)Hmgu | homozygote | Early adult | 1.67x10-11 | ||
| increased heart weight | 1 supporting dataset | Serf1tm1a(EUCOMM)Hmgu | homozygote | Early adult | 4.88x10-5 | ||
| decreased CD8-positive, alpha-beta T cell number | 1 supporting dataset | Serf1tm1a(EUCOMM)Hmgu | homozygote | Early adult | 2.3x10-5 |
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Human diseases caused by Serf1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Serf1.
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| Serf1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Serf1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Serf1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |