Ap4m1 | adaptor-related protein complex AP-4, mu 1

GeneMGI:1337063Synonyms: 4930443L05Rik

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased leukocyte cell number	1 supporting dataset	Ap4m1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.1x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Ap4m1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.94x10^-11
increased hematocrit	1 supporting dataset	Ap4m1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.48x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Ap4m1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.71x10^-7
increased circulating iron level	1 supporting dataset	Ap4m1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.79x10^-5
increased circulating cholesterol level	1 supporting dataset	Ap4m1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.82x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Ap4m1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.85x10^-33
decreased circulating serum albumin level	1 supporting dataset	Ap4m1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.1x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ap4m1.

Associated images

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Histopathology

There is no histopathology data found for Ap4m1.

IMPC related publications

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External links

No external links available for Ap4m1.

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*Ap4m1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Ap4m1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ap4m1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ap4m1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Ap4m1^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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