Ap4m1 | adaptor-related protein complex AP-4, mu 1
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hematopoietic system
15 No significant impact
6 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased leukocyte cell number | 1 supporting dataset | Ap4m1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.1x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Ap4m1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.94x10-11 | ||
| increased hematocrit | 1 supporting dataset | Ap4m1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.48x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Ap4m1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.71x10-7 | ||
| increased circulating iron level | 1 supporting dataset | Ap4m1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.79x10-5 | ||
| increased circulating cholesterol level | 1 supporting dataset | Ap4m1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.82x10-5 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Ap4m1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.85x10-33 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Ap4m1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.1x10-7 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/1) | 0.41% (2/491) |
Human diseases caused by Ap4m1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ap4m1.
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| Ap4m1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ap4m1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ap4m1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ap4m1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Ap4m1tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |