Lss | lanosterol synthase
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Mortality/aging
16 No significant impact
3 Not tested
Data collections
Gene metrics:8Significant phenotypes
7Associated diseases
Expression examined in:49Adult tissues
62Embryo tissues
| preweaning lethality, complete penetrance | 4 supporting datasets | Lsstm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Lsstm1b(KOMP)Wtsi | heterozygote | Early adult | 3.31x10-6 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Lsstm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal lens morphology | 1 supporting dataset | Lsstm1b(KOMP)Wtsi | heterozygote | Early adult | 9.57x10-6 | ||
| increased leukocyte cell number | 1 supporting dataset | Lsstm1b(KOMP)Wtsi | heterozygote | Early adult | 4.12x10-5 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Lsstm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Lss mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Lss.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Lsstm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Lsstm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Lsstm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |