Lss | lanosterol synthase
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Mortality/aging
16 No significant impact
3 Not tested
Data collections
Gene metrics:8Significant phenotypes
7Associated diseases
Expression examined in:49Adult tissues
62Embryo tissues
| preweaning lethality, complete penetrance | 4 supporting datasets | Lsstm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Lsstm1b(KOMP)Wtsi | heterozygote | Early adult | 3.31x10-6 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Lsstm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal lens morphology | 1 supporting dataset | Lsstm1b(KOMP)Wtsi | heterozygote | Early adult | 9.57x10-6 | ||
| increased leukocyte cell number | 1 supporting dataset | Lsstm1b(KOMP)Wtsi | heterozygote | Early adult | 4.12x10-5 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Lsstm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * |
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External links
No external links available for Lss.
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| Lsstm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Lsstm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Lsstm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |