Pstpip2 | proline-serine-threonine phosphatase-interacting protein 2

GeneMGI:1335088Synonyms: cmo

Physiological systems

19 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Limbs/digits/tail Liver/biliary system Hematopoietic system Behavior/neurological Skeleton

9 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased exploration in new environment	1 supporting dataset	Pstpip2^em1(IMPC)Tcp	homozygote	Early adult	6.58x10^-6
abnormal digit morphology	2 supporting datasets	Pstpip2^em1(IMPC)Tcp	homozygote	Early adult	4.89x10^-16
decreased erythrocyte cell number	1 supporting dataset	Pstpip2^em1(IMPC)Tcp	homozygote	Early adult	3.84x10^-5
abnormal liver morphology	1 supporting dataset	Pstpip2^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Pstpip2^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
improved glucose tolerance	1 supporting dataset	Pstpip2^em1(IMPC)Tcp	homozygote	Early adult	4.59x10^-5
decreased grip strength	1 supporting dataset	Pstpip2^em1(IMPC)Tcp	homozygote	Early adult	2.62x10^-5
enlarged lymph nodes	2 supporting datasets	Pstpip2^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Pstpip2^em1(IMPC)Tcp	homozygote	Early adult	4.79x10^-10
abnormal vertebrae morphology	1 supporting dataset	Pstpip2^em1(IMPC)Tcp	homozygote	Early adult	4.09x10^-14

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pstpip2.

Associated images

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Histopathology

There is no histopathology data found for Pstpip2.

IMPC related publications

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External links

No external links available for Pstpip2.

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*Pstpip2^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Pstpip2^{tm448163(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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