Pstpip2 | proline-serine-threonine phosphatase-interacting protein 2
Physiological systems
19 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Limbs/digits/tail Liver/biliary system Hematopoietic system Behavior/neurological Skeleton
9 No significant impact
5 Not tested
Data collections
Gene metrics:15Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased exploration in new environment | 1 supporting dataset | Pstpip2em1(IMPC)Tcp | homozygote | Early adult | 6.58x10-6 | ||
| abnormal digit morphology | 2 supporting datasets | Pstpip2em1(IMPC)Tcp | homozygote | Early adult | 4.89x10-16 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Pstpip2em1(IMPC)Tcp | homozygote | Early adult | 3.84x10-5 | ||
| abnormal liver morphology | 1 supporting dataset | Pstpip2em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| abnormal seminal vesicle morphology | 1 supporting dataset | Pstpip2em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| improved glucose tolerance | 1 supporting dataset | Pstpip2em1(IMPC)Tcp | homozygote | Early adult | 4.59x10-5 | ||
| decreased grip strength | 1 supporting dataset | Pstpip2em1(IMPC)Tcp | homozygote | Early adult | 2.62x10-5 | ||
| enlarged lymph nodes | 2 supporting datasets | Pstpip2em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Pstpip2em1(IMPC)Tcp | homozygote | Early adult | 4.79x10-10 | ||
| abnormal vertebrae morphology | 1 supporting dataset | Pstpip2em1(IMPC)Tcp | homozygote | Early adult | 4.09x10-14 |
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Human diseases caused by Pstpip2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Pstpip2.
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| Pstpip2em1(IMPC)Tcp | Exon Deletion | | mouse |
| Pstpip2tm448163(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |