Lats1 | large tumor suppressor

GeneMGI:1333883

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Nervous system Hematopoietic system Behavior/neurological

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased grip strength	3 supporting datasets	Lats1^em1(IMPC)H	homozygote	Early adult	3.48x10^-9
decreased grip strength	2 supporting datasets	Lats1^em1(IMPC)H	heterozygote	Early adult	1.31x10^-6
decreased locomotor activity	3 supporting datasets	Lats1^em1(IMPC)H	homozygote	Early adult	2.27x10^-8
increased neutrophil cell number	1 supporting dataset	Lats1^em1(IMPC)H	homozygote	Early adult	7.8x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Lats1^em1(IMPC)H	homozygote	Early adult	1.95x10^-5
decreased prepulse inhibition	1 supporting dataset	Lats1^em1(IMPC)H	homozygote	Early adult	1.45x10^-5
decreased hemoglobin content	1 supporting dataset	Lats1^em1(IMPC)H	homozygote	Early adult	1.14x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lats1.

Associated images

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Histopathology

There is no histopathology data found for Lats1.

IMPC related publications

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External links

No external links available for Lats1.

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*Lats1^em1(IMPC)H*	Exon Deletion	‌	mouse
*Lats1^em2(IMPC)H*	Exon Deletion	‌	mouse

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