Dclk1 | doublecortin-like kinase 1
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Behavior/neurological
14 No significant impact
6 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased anti-nuclear antigen antibody level | 4 supporting datasets | Dclk1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| decreased circulating magnesium level | 1 supporting dataset | Dclk1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.31x10-6 | ||
| increased anti-nuclear antigen antibody level | 4 supporting datasets | Dclk1tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Dclk1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.33x10-5 | ||
| increased grip strength | 1 supporting dataset | Dclk1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 5.78x10-6 | ||
| increased grip strength | 1 supporting dataset | Dclk1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.61x10-6 | ||
| decreased body length | 1 supporting dataset | Dclk1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.8x10-5 |
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Human diseases caused by Dclk1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dclk1.
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| Dclk1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dclk1tm240457(L1L2_Bact_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |
| Dclk1tm438463(L1L2_GT1_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |