Dpm2 | dolichyl-phosphate mannosyltransferase subunit 2, regulatory

GeneMGI:1330238

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Mortality/aging Cardiovascular system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating total protein level	1 supporting dataset	Dpm2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.37x10^-6
impaired glucose tolerance	1 supporting dataset	Dpm2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.88x10^-7
enlarged heart	1 supporting dataset	Dpm2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Dpm2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dpm2.

Associated images

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Histopathology

There is no histopathology data found for Dpm2.

IMPC related publications

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External links

No external links available for Dpm2.

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*Dpm2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Dpm2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Dpm2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dpm2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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