Orc1 | origin recognition complex, subunit 1

GeneMGI:1328337Synonyms: Orc1l, MmORC1

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Adipose tissue Growth/size/body region Behavior/neurological Skeleton Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



embryonic lethality prior to organogenesis	1 supporting dataset	Orc1^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Orc1^{tm1a(KOMP)Wtsi}	homozygote	E15.5	N/A ^*
increased bone mineral density	1 supporting dataset	Orc1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	2.79x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Orc1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased grip strength	1 supporting dataset	Orc1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	2.53x10^-5
decreased total body fat amount	1 supporting dataset	Orc1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.4x10^-7
increased lean body mass	2 supporting datasets	Orc1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.93x10^-9
preweaning lethality, complete penetrance	1 supporting dataset	Orc1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased bone mineral content	1 supporting dataset	Orc1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.98x10^-7
embryonic lethality prior to organogenesis	1 supporting dataset	Orc1^{tm1a(KOMP)Wtsi}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Orc1.

Associated images

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Histopathology

There is no histopathology data found for Orc1.

IMPC related publications

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External links

No external links available for Orc1.

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*Orc1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Orc1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Orc1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Orc1^{tm295368(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Orc1^{tm36556(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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