Orc1 | origin recognition complex, subunit 1
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Adipose tissue Growth/size/body region Behavior/neurological Skeleton Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| embryonic lethality prior to organogenesis | 1 supporting dataset | Orc1tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Orc1tm1a(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| increased bone mineral density | 1 supporting dataset | Orc1tm1a(KOMP)Wtsi | heterozygote | Early adult | 2.79x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Orc1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased grip strength | 1 supporting dataset | Orc1tm1a(KOMP)Wtsi | heterozygote | Early adult | 2.53x10-5 | ||
| decreased total body fat amount | 1 supporting dataset | Orc1tm1a(KOMP)Wtsi | heterozygote | Early adult | 1.4x10-7 | ||
| increased lean body mass | 2 supporting datasets | Orc1tm1a(KOMP)Wtsi | heterozygote | Early adult | 1.93x10-9 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Orc1tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased bone mineral content | 1 supporting dataset | Orc1tm1a(KOMP)Wtsi | heterozygote | Early adult | 1.98x10-7 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Orc1tm1a(KOMP)Wtsi | homozygote | E9.5 | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Orc1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Orc1.
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| Orc1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Orc1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Orc1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Orc1tm295368(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Orc1tm36556(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |