Trex1 | three prime repair exonuclease 1

Physiological systems

20 / 24 physiological systems tested

15 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Hematopoietic system Cardiovascular system Craniofacial Renal/urinary system Homeostasis/metabolism Limbs/digits/tail Vision/eye Liver/biliary system Skeleton

5 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:41Significant phenotypes

8Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased neutrophil cell number	2 supporting datasets	Trex1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.16x10^-7
enlarged spleen	2 supporting datasets	Trex1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased lymphocyte cell number	1 supporting dataset	Trex1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.04x10^-13
abnormal testis morphology	1 supporting dataset	Trex1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Trex1^{em1(IMPC)Ccpcz}	homozygote	Early adult	8.34x10^-22
abnormal skin morphology	1 supporting dataset	Trex1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Trex1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Trex1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged heart	2 supporting datasets	Trex1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal lens morphology	1 supporting dataset	Trex1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	9.12x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Trex1.

Associated images

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Histopathology

There is no histopathology data found for Trex1.

IMPC related publications

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External links

No external links available for Trex1.

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*Trex1^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Trex1^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse

My Genes