Trex1 | three prime repair exonuclease 1
GeneMGI:1328317
Physiological systems
20 / 24 physiological systems tested
15 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Hematopoietic system Cardiovascular system Craniofacial Renal/urinary system Homeostasis/metabolism Limbs/digits/tail Vision/eye Liver/biliary system Skeleton
5 No significant impact
4 Not tested
Data collections
Gene metrics:41Significant phenotypes
8Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased neutrophil cell number | 2 supporting datasets | Trex1em1(IMPC)Ccpcz | homozygote | Early adult | 4.16x10-7 | ||
| enlarged spleen | 2 supporting datasets | Trex1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased lymphocyte cell number | 1 supporting dataset | Trex1em1(IMPC)Ccpcz | homozygote | Early adult | 1.04x10-13 | ||
| abnormal testis morphology | 1 supporting dataset | Trex1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased red blood cell distribution width | 1 supporting dataset | Trex1em1(IMPC)Ccpcz | homozygote | Early adult | 8.34x10-22 | ||
| abnormal skin morphology | 1 supporting dataset | Trex1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 2 supporting datasets | Trex1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 2 supporting datasets | Trex1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| enlarged heart | 2 supporting datasets | Trex1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal lens morphology | 1 supporting dataset | Trex1em1(IMPC)Ccpcz | heterozygote | Early adult | 9.12x10-5 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 100% (2/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/1) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Trex1.
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| Trex1em1(IMPC)Ccpcz | Intra-exon deletion | | mouse |
| Trex1tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |