Ly86 | lymphocyte antigen 86

GeneMGI:1321404Synonyms: MD1, MD-1

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Cardiovascular system

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating aspartate transaminase level	1 supporting dataset	Ly86^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	0
increased heart weight	2 supporting datasets	Ly86^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.44x10^-8
decreased total body fat amount	1 supporting dataset	Ly86^{tm1a(KOMP)Wtsi}	homozygote	Early adult	9.37x10^-5
decreased total body fat amount	1 supporting dataset	Ly86^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	7.36x10^-11
increased lymphocyte cell number	1 supporting dataset	Ly86^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	2.08x10^-9
increased lymphocyte cell number	1 supporting dataset	Ly86^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.46x10^-6
increased leukocyte cell number	1 supporting dataset	Ly86^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.1x10^-5
increased lean body mass	2 supporting datasets	Ly86^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.05x10^-5
increased leukocyte cell number	1 supporting dataset	Ly86^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.73x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression



adrenal gland	heterozygote	n/a	0% (0/2)	0.7% (4/570)
aorta	heterozygote	n/a	0% (0/2)	0.19% (1/533)
blood	heterozygote	n/a	0% (0/1)	0% (0/17)
bone marrow	heterozygote	n/a	0% (0/1)	0% (0/22)
brain	heterozygote	n/a	0% (0/2)	0.86% (5/579)
brainstem	heterozygote	n/a	n/a	0.41% (2/490)
brown adipose tissue	heterozygote	n/a	0% (0/2)	0% (0/588)
cartilage tissue	heterozygote	n/a	n/a	0.22% (1/454)
cecum	heterozygote	n/a	0% (0/1)	7.75% (22/284)
cerebellum	heterozygote	n/a	0% (0/2)	0.56% (3/532)

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Associated images

7 images

Adult LacZ

LacZ Images Section

Histopathology

There is no histopathology data found for Ly86.

IMPC related publications

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External links

No external links available for Ly86.

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*Ly86^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse

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