Pstpip1 | proline-serine-threonine phosphatase-interacting protein 1

GeneMGI:1321396Synonyms: def-2, CD2BP1

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Liver/biliary system Hematopoietic system Skeleton Renal/urinary system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal kidney morphology	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased kidney weight	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.73x10^-8
abnormal spleen morphology	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased CD4-positive, alpha-beta T cell number	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.74x10^-5
enlarged spleen	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
lordosis	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.29x10^-5
enlarged liver	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating total protein level	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.79x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pstpip1.

Associated images

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Histopathology

There is no histopathology data found for Pstpip1.

IMPC related publications

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External links

No external links available for Pstpip1.

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*Pstpip1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Pstpip1^{tm44607(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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