Pstpip1 | proline-serine-threonine phosphatase-interacting protein 1

GeneMGI:1321396Synonyms: def-2, CD2BP1

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Liver/biliary system Hematopoietic system Skeleton Renal/urinary system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal kidney morphology	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased kidney weight	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.73x10^-8
abnormal spleen morphology	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased CD4-positive, alpha-beta T cell number	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.74x10^-5
enlarged spleen	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
lordosis	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.29x10^-5
enlarged liver	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating total protein level	1 supporting dataset	Pstpip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.79x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pstpip1.

Associated images

16 images

X-ray

XRay Images Forepaw

32 images

X-ray

XRay Images Hind Leg and Hip

16 images

X-ray

XRay Images Skull Dorso Ventral Orientation

16 images

X-ray

XRay Images Skull Lateral Orientation

32 images

X-ray

XRay Images Whole Body Dorso Ventral

16 images

X-ray

XRay Images Whole Body Lateral Orientation

Human diseases caused by Pstpip1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



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Histopathology

There is no histopathology data found for Pstpip1.

IMPC related publications

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External links

No external links available for Pstpip1.

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*Pstpip1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Pstpip1^{tm44607(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes

Pstpip1 | proline-serine-threonine phosphatase-interacting protein 1

Physiological systems

8 Significantly impacted by the knock-out

12 No significant impact

4 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

X-ray

X-ray

X-ray

X-ray

X-ray

X-ray

Human diseases caused by Pstpip1 mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data