Rad1 | RAD1 checkpoint DNA exonuclease

GeneMGI:1316678

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Vision/eye Hematopoietic system Skeleton Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased fasting circulating glucose level	1 supporting dataset	Rad1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.8x10^-6
decreased circulating iron level	1 supporting dataset	Rad1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.16x10^-5
abnormal embryo turning	1 supporting dataset	Rad1^{tm1b(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
decreased circulating HDL cholesterol level	1 supporting dataset	Rad1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	9.45x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Rad1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Rad1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased hematocrit	1 supporting dataset	Rad1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.97x10^-5
abnormal bone structure	1 supporting dataset	Rad1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.81x10^-5
abnormal lens morphology	1 supporting dataset	Rad1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.64x10^-6
increased erythrocyte cell number	1 supporting dataset	Rad1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.59x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rad1.

Associated images

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Histopathology

There is no histopathology data found for Rad1.

IMPC related publications

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External links

No external links available for Rad1.

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*Rad1^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Rad1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rad1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rad1^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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