Rad1 | RAD1 checkpoint DNA exonuclease
GeneMGI:1316678
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Vision/eye Hematopoietic system Skeleton Mortality/aging
14 No significant impact
4 Not tested
Data collections
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| increased fasting circulating glucose level | 1 supporting dataset | Rad1tm1b(KOMP)Wtsi | heterozygote | Early adult | 5.8x10-6 | ||
| decreased circulating iron level | 1 supporting dataset | Rad1tm1b(KOMP)Wtsi | heterozygote | Early adult | 5.16x10-5 | ||
| abnormal embryo turning | 1 supporting dataset | Rad1tm1b(KOMP)Wtsi | heterozygote | E9.5 | N/A * | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Rad1tm1b(KOMP)Wtsi | heterozygote | Early adult | 9.45x10-5 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Rad1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Rad1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased hematocrit | 1 supporting dataset | Rad1tm1b(KOMP)Wtsi | heterozygote | Early adult | 2.97x10-5 | ||
| abnormal bone structure | 1 supporting dataset | Rad1tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.81x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Rad1tm1b(KOMP)Wtsi | heterozygote | Early adult | 3.64x10-6 | ||
| increased erythrocyte cell number | 1 supporting dataset | Rad1tm1b(KOMP)Wtsi | heterozygote | Early adult | 8.59x10-6 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | n/a | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
External links
No external links available for Rad1.
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| Rad1tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Rad1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rad1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rad1tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |