Slc40a1 | solute carrier family 40 (iron-regulated transporter), member 1
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
3Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| decreased bone mineral content | 2 supporting datasets | Slc40a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.7x10-10 | ||
| decreased bone mineral density | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.27x10-5 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased circulating triglyceride level | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.23x10-6 | ||
| decreased lean body mass | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.19x10-6 | ||
| increased total body fat amount | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.87x10-5 |
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External links
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| Slc40a1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell mouse |
| Slc40a1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |