Slc40a1 | solute carrier family 40 (iron-regulated transporter), member 1
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
3Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| decreased bone mineral content | 2 supporting datasets | Slc40a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.7x10-10 | ||
| decreased bone mineral density | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.27x10-5 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased circulating triglyceride level | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.23x10-6 | ||
| decreased lean body mass | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.19x10-6 | ||
| increased total body fat amount | 1 supporting dataset | Slc40a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.87x10-5 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Slc40a1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Slc40a1.
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| Slc40a1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Slc40a1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |