Emg1 | EMG1 N1-specific pseudouridine methyltransferase

GeneMGI:1315195Synonyms: Grcc2f

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Mortality/aging

17 No significant impact

4 Not tested

Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues

Phenotypes

decreased total retina thickness2 supporting datasetsEmg1tm1.1(KOMP)WtsiheterozygoteEarly adult4.59x10-7 
preweaning lethality, complete penetrance3 supporting datasetsEmg1tm1.1(KOMP)WtsihomozygoteEarly adultN/A * 
embryonic lethality prior to organogenesis1 supporting datasetEmg1tm1.1(KOMP)WtsihomozygoteE9.5N/A * 
abnormal retina inner nuclear layer morphology2 supporting datasetsEmg1tm1.1(KOMP)WtsiheterozygoteEarly adult1.26x10-6 
decreased circulating aspartate transaminase level1 supporting datasetEmg1tm1.1(KOMP)WtsiheterozygoteEarly adult1.46x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Emg1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Emg1tm1(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
mouse
Emg1tm1.1(KOMP)WtsiReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Emg1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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