Afdn | afadin, adherens junction formation factor

GeneMGI:1314653Synonyms: Afadin, AF6, +4 more

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Embryo Growth/size/body region Digestive/alimentary Nervous system Liver/biliary system Hematopoietic system Mortality/aging Renal/urinary system

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:23Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased lymphocyte cell number	1 supporting dataset	Afdn^em1(IMPC)Mbp	heterozygote	Early adult	9.07x10^-5
abnormal hindbrain development	1 supporting dataset	Afdn^em1(IMPC)Mbp	heterozygote	E9.5	N/A ^*
enlarged lymph nodes	1 supporting dataset	Afdn^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Afdn^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
decreased prepulse inhibition	1 supporting dataset	Afdn^em1(IMPC)Mbp	heterozygote	Early adult	6.21x10^-5
abnormal spleen morphology	2 supporting datasets	Afdn^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
enlarged spleen	2 supporting datasets	Afdn^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Afdn^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Afdn^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
decreased spleen weight	1 supporting dataset	Afdn^em1(IMPC)Mbp	heterozygote	Early adult	2.62x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Afdn.

Associated images

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Histopathology

There is no histopathology data found for Afdn.

IMPC related publications

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External links

No external links available for Afdn.

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*Afdn^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Afdn^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Afdn^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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