Afdn | afadin, adherens junction formation factor
Physiological systems
22 / 24 physiological systems tested
12 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Integument Embryo Growth/size/body region Digestive/alimentary Nervous system Liver/biliary system Hematopoietic system Mortality/aging Renal/urinary system
10 No significant impact
2 Not tested
Data collections
Gene metrics:23Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased lymphocyte cell number | 1 supporting dataset | Afdnem1(IMPC)Mbp | heterozygote | Early adult | 9.07x10-5 | ||
| abnormal hindbrain development | 1 supporting dataset | Afdnem1(IMPC)Mbp | heterozygote | E9.5 | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Afdnem1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal liver morphology | 1 supporting dataset | Afdnem1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| decreased prepulse inhibition | 1 supporting dataset | Afdnem1(IMPC)Mbp | heterozygote | Early adult | 6.21x10-5 | ||
| abnormal spleen morphology | 2 supporting datasets | Afdnem1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| enlarged spleen | 2 supporting datasets | Afdnem1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Afdnem1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal lymph node morphology | 1 supporting dataset | Afdnem1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| decreased spleen weight | 1 supporting dataset | Afdnem1(IMPC)Mbp | heterozygote | Early adult | 2.62x10-5 |
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Human diseases caused by Afdn mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Afdn.
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| Afdnem1(IMPC)Mbp | Exon Deletion | | mouse |
| Afdntm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Afdntm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |