Gsta4 | glutathione S-transferase, alpha 4
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Pigmentation Integument Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
5 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| shortened PQ interval | 1 supporting dataset | Gsta4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.17x10-5 | ||
| abnormal vitreous body morphology | 1 supporting dataset | Gsta4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.68x10-5 | ||
| increased red blood cell distribution width | 1 supporting dataset | Gsta4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.3x10-8 | ||
| decreased exploration in new environment | 1 supporting dataset | Gsta4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.89x10-5 | ||
| abnormal coat/hair pigmentation | 3 supporting datasets | Gsta4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.04x10-6 | ||
| abnormal lens morphology | 1 supporting dataset | Gsta4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.19x10-5 | ||
| abnormal retina morphology | 1 supporting dataset | Gsta4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.91x10-5 | ||
| increased startle reflex | 1 supporting dataset | Gsta4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.51x10-5 |
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Human diseases caused by Gsta4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gsta4.
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| Gsta4tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gsta4tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Gsta4tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |