Casq2 | calsequestrin 2

GeneMGI:1309469Synonyms: ESTM52, cCSQ, +2 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Cardiovascular system Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

2Associated diseases

Expression examined in:42Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



cardiovascular system phenotype	1 supporting dataset	Casq2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.32x10^-10
preweaning lethality, complete penetrance	3 supporting datasets	Casq2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal sinus arrhythmia	1 supporting dataset	Casq2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.01x10^-7
edema	1 supporting dataset	Casq2^{tm1b(KOMP)Wtsi}	homozygote	E15.5	N/A ^*
decreased heart rate variability	1 supporting dataset	Casq2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.44x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Casq2.

Associated images

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Histopathology

There is no histopathology data found for Casq2.

IMPC related publications

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External links

No external links available for Casq2.

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*Casq2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Casq2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Casq2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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