Dhcr7 | 7-dehydrocholesterol reductase
GeneMGI:1298378
Physiological systems
22 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Embryo Growth/size/body region Vision/eye Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system
13 No significant impact
2 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal placenta morphology | 1 supporting dataset | Dhcr7em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| abnormal placenta vasculature | 1 supporting dataset | Dhcr7em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| edema | 1 supporting dataset | Dhcr7em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal placenta morphology | 1 supporting dataset | Dhcr7em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal blood vessel morphology | 1 supporting dataset | Dhcr7em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Dhcr7em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| enlarged spleen | 1 supporting dataset | Dhcr7em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Dhcr7em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| microphthalmia | 1 supporting dataset | Dhcr7em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| small kidney | 1 supporting dataset | Dhcr7em1(IMPC)Mbp | heterozygote | Early adult | N/A * |
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Human diseases caused by Dhcr7 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dhcr7.
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| Dhcr7em1(IMPC)Mbp | Exon Deletion | | mouse |
| Dhcr7tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dhcr7tm44428(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |