Dhcr7 | 7-dehydrocholesterol reductase

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Embryo Growth/size/body region Vision/eye Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal placenta morphology	1 supporting dataset	Dhcr7^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal placenta vasculature	1 supporting dataset	Dhcr7^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
edema	1 supporting dataset	Dhcr7^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Dhcr7^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal blood vessel morphology	1 supporting dataset	Dhcr7^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal spleen morphology	1 supporting dataset	Dhcr7^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Dhcr7^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Dhcr7^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
microphthalmia	1 supporting dataset	Dhcr7^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
small kidney	1 supporting dataset	Dhcr7^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dhcr7.

Associated images

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Histopathology

There is no histopathology data found for Dhcr7.

IMPC related publications

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External links

No external links available for Dhcr7.

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*Dhcr7^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Dhcr7^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dhcr7^{tm44428(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes