Slc7a5 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5

GeneMGI:1298205Synonyms: D0H16S474E, LAT1, +2 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Hematopoietic system Mortality/aging

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetSlc7a5em1(IMPC)HhomozygoteEarly adultN/A * 
increased circulating potassium level1 supporting datasetSlc7a5em1(IMPC)HheterozygoteEarly adult2.32x10-5 
increased basophil cell number1 supporting datasetSlc7a5em1(IMPC)HheterozygoteEarly adult4.74x10-5 
increased mean corpuscular volume1 supporting datasetSlc7a5em1(IMPC)HheterozygoteEarly adult6.81x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Slc7a5em1(IMPC)HExon Deletionmouse
Slc7a5em2(IMPC)HExon Deletionmouse
Slc7a5tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Slc7a5tm85615(L1L2_Pgk_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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